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Topology, Statistics, and Tumors in Mice

by

Professor Dave Damiano
College of the Holy Cross

April 5, 2016
5:00 pm
Bailey Hall 207

Refreshments will be served in Bailey Hall 204 4:45pm


Abstract:

Mouse models are used to test the delivery of drugs to tumors. A primary method of drug delivery involves using targeted antibodies that bind to antigens on the surface of tumor cells. In order to track the delivery of antibody to tumor, antibodies are labeled by a radioactive tracer. In this talk we will describe a novel method of analyzing the uptake of radio-labeled antibodies by tumor that combines topology and statistics, specifically persistent homology and hypothesis testing. Along the way, we will present background in each area and discuss the application of this method to SPECT (Single-photon emission computed tomography) images from two pre-clinical studies of antibody targeting of tumors.


For additional information, send e-mail to math@union.edu or call (518) 388-6246.
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